Malignant Neoplasms

In a existence of mainly European origin, a substantial proportion of the increase incidence is attributable to a steady transform from preponderantly occupational to predominantly recreational exposure to solar radiation, tally to these authors.

In the United States, the incidence of melanoma varies with latitude, with more than trinity times as many cases in the South (8). Americans harbor a iodin in 84 risk of growth melanoma (4). The risk has increased from one in 1,500 67 years ago, to one in 250 in 1980, and is predicted to be one in 75 by the year 2,000 (3). Other countries, including Australia, Austria, Canada, Germany, Italy, and Scotland bind also reported such increases. The overall incidence stray for melanoma is increasing faster than the rate for any some other cancer.

Diagnosis of melanoma is usually made initially by a history and physical examination (28). Two unalike checklists contrive been devised to help in diagnosis of melanoma. The first, the ABCD list, looks at imbalance (A), border irregularity (B), color variegation (C), and diameter (D) when the diameter is greater than sic mm.

The seven-point system includes three major criteria - change in size, shape, and color - and four minor criteria - inflammation, crusting or bleeding, afferent change, and a diameter greater than or equal to 7 mm.

25. Straume, O.; Akslen, L. A. Independent prognostic importance of vascular invasion in nodular melanoma. Cancer periodical Plus. Oct.21:35; 1996.

14. Kefford, R. P. The p16 INK4a-CDK4-RB pathway as a potential

28. Whited, J. D.; Grichnik, J. M. Does this patient have a mole or a melanoma? JAMA:696-671; 1998.

19. Piepkorn, M. notional and empirical arguments in

20. Platz, A.; Hansson, J.; Mansson-Brahme, E.; Lagerlof, B.;

A.; Orfanos, C. E.; Peters, A.; Rassner, G.; Stadler, R.;

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